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Cancer-related glycopeptide epitopes, antibodies and methods of use
专利权人:
Shin-Ichiro Nishimura
发明人:
Shin-Ichiro Nishimura,Takahiko Matsushita,Yoshiaki Miura
申请号:
US13641610
公开号:
US09346867B2
申请日:
2011.04.15
申请国别(地区):
US
年份:
2016
代理人:
摘要:
Cancer-associated O-glycopeptide combination epitopes derived from the VNTR of MUC1 are disclosed. Autoantibodies present in human sera target the combination epitopes and are reduced or absent in cancer patients. The epitopes are useful as therapeutic and immunoprophylactic cancer vaccines. Monoclonal antibodies directed against the epitopes are also useful as immunotherapeutics for treatment and prevention of cancer. Diagnostic methods using the epitopes and antibodies are also disclosed.
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