CANCER-RELATED GLYCOPEPTIDE EPITOPES, ANTIBODIES AND METHODS OF USE

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专利权人:

发明人:

申请号：

EP11717110.8

公开号：

EP2560989B1

申请日:

2011.04.15

申请国别(地区):

EP

年份:

2017

代理人:

摘要：

Cancer-associated O-glycopeptide combination epitopes derived from the VNTR of MUC1 are disclosed. Autoantibodies present in human sera target the combination epitopes and are reduced or absent in cancer patients. The epitopes are useful as therapeutic and immunoprophylactic cancer vaccines. Monoclonal antibodies directed against the epitopes are also useful as immunotherapeutics for treatment and prevention of cancer. Diagnostic methods using the epitopes and antibodies are also disclosed.

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中国工程科技知识中心

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http://www.ckcest.cn/home/