Oregon Health & Science University;Hansen, Scott;Sacha, Jonah;Früh, Klaus;Picker, Louis
发明人:
FRUEH, Klaus,PICKER, Louis,HANSEN, Scott,SACHA, Jonah,MALOULI, Daniel
申请号：
EP16749813
公开号：
EP3256595A4
申请日:
2016.02.10
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
Methods of inducing a CD8+ T cell response to a heterologous antigen in which at least 10% of the CD8+ T cells are MHC-E restricted are disclosed. The method involves immunizing with a CMV vector that does not express UL128 and UL130 proteins. Also disclosed are recombinant CMV vectors comprising nucleic acids encoding a heterologous protein antigen, a UL40 protein, and a US28 protein but that do not express an active UL128 and UL130 protein. Also disclosed are recombinant CMV vectors comprising nucleic acids encoding a heterologous protein antigen, but that do not express an active UL40 protein, UL128 protein, UL130 protein, and optionally a US28 protein. Also disclosed are recombinant CMV vectors comprising nucleic acids encoding a heterologous protein antigen, but that do not express an active US28 protein, UL128 protein, UL130 protein, and optionally a UL40 protein.
