OREGON HEALTH & SCIENCE UNIVERSITY;FRUEH, KLAUS;HANSEN, SCOTT;SACHA, JONAH;PICKER, LOUIS
发明人:
FRUEH, KLAUS,PICKER, LOUIS,HANSEN, SCOTT,SACHA, JONAH,MALOULI, DANIEL
申请号：
CA2976245
公开号：
CA2976245A1
申请日:
2016.02.10
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
Methods of inducing a CD8+ T cell response to a heterologous antigen in which at least 10% of the CD8+ T cells are MHC-E restricted are disclosed. The method involves immunizing with a CMV vector that does not express UL128 and UL130 proteins. Also disclosed are recombinant CMV vectors comprising nucleic acids encoding a heterologous protein antigen, a UL40 protein, and a US28 protein but that do not express an active UL128 and UL130 protein. Also disclosed are recombinant CMV vectors comprising nucleic acids encoding a heterologous protein antigen, but that do not express an active UL40 protein, UL128 protein, UL130 protein, and optionally a US28 protein. Also disclosed are recombinant CMV vectors comprising nucleic acids encoding a heterologous protein antigen, but that do not express an active US28 protein, UL128 protein, UL130 protein, and optionally a UL40 protein.
