The present invention pertains to a compound having an exceptional effect for inhibiting retinoic-acid-receptor-related orphan receptors γt, or a pharmacologically acceptable salt thereof. A compound represented by general formula (I) (in the formula, R1 represents a C1-C6 alkyl group, a C3-C6 cycloalkyl group, or a phenyl group R2 represents a hydrogen atom, a halogen atom, a C1-C6 alkyl group, or the like R3 represents a hydrogen atom, a C2-C7 carboxyalkyl group, or a hydroxyl group R4 represents a halogen atom or a C1-C6 alkyl group R5 represents a hydrogen atom or a C1-C6 alkyl group R6 represents a hydrogen atom, a halogen atom, or a C1-C6 alkyl group Q1 represents a nitrogen atom or a group represented by the formula =CH- Q2 represents a nitrogen atom or a group represented by the formula =CH- a group represented by the formula -U-T- represents a group represented by the formula -CH2-CH2-, or the like Y represents a methylene group or an oxygen atom V represents a nitrogen atom or a group represented by the formula =C(R7)- R7 represents a hydrogen atom, a halogen atom, a C1-C6 alkyl group, or the like E represents a piperidine-1-yl group, piperidine-4-yl group, or 1,2,3,6-tetrahydropyridine-4-yl group optionally substituted independently by from one to four groups selected from substituent group A, or the like substituent group A includes C1-C6 alkyl groups, C1-C6 alkyl halide groups, groups represented by the formula -L-R8, and the like L represents a carbonyl group, an oxalyl group, or the like R8 represents a C1-C6 alkyl group, a C1-C6 hydroxyalkyl group, a mono-C1-C6 alkylamino group, or the like), or a pharmacologically acceptable salt thereof.La présente invention se rapporte à un composé ayant un effet exceptionnel dinhibition des récepteurs γt orphelins liés aux récepteurs de lacide rétinoique, ou un sel pharmacologiquement acceptable de celui-ci. Linvention concerne un composé représenté par la formule générale (I) (dans laquelle : R1 représente un gr
