Tarek A. Zeidan,Scott Duncan,Christopher P. Hencken,Thomas Andrew Wynn,Carlos N. Sanrame
申请号：
US14032736
公开号：
US08669281B1
申请日:
2013.09.20
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention provides compounds of formula (I),wherein:R1 is unsubstituted C1-C6 alkyl；La is substituted or unsubstituted C1-C6 alkyl linker, substituted or unsubstituted C3-C10 carbocycle, substituted or unsubstituted heterocycle comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S, or substituted or unsubstituted heteroaryl comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S； andR2 and R3 are each, independently, H, substituted or unsubstituted C1-C6 alkyl, or substituted or unsubstituted C6-C10 aryl；or alternatively, R2 and R3, together with the nitrogen atom to which they are attached, form a substituted or unsubstituted heteroaryl comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S or a substituted or unsubstituted heterocycle comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S.The invention also provides pharmaceutical compositions and methods for treating neurological diseases, such as multiple sclerosis.
