INC.;H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE
发明人:
ANTONIA, SCOTT,CHIAPPORI, ALBERTO
申请号:
CA2985055
公开号:
CA2985055A1
申请日:
2016.04.04
申请国别(地区):
CA
年份:
2016
代理人:
摘要:
A method is disclosed for treating small cell lung cancer (SCLC) in a subject that involves administering to the subject a therapeutically effective amount of dendritic cells engineered to overexpress p53. In some embodiments, the method further involves administering to the subject a therapeutically effective amount of all-trans-retinoic acid (ATRA). The method can also involve administering to the subject a therapeutically effective amount of an immune checkpoint inhibitor.