ANDERS POULSEN,ANDERS POULSEN,CHENG SAN BRIAN CHIA,CHENG SAN BRIAN CHIA,CHUHUI HUANG,CHUHUI HUANG,JIN YAN MELGIOUS ANG,JIN YAN MELGIOUS ANG,KLEMENT JIHAO FOO,KLEMENT JIHAO FOO,SI SI LIEW,SI SI LIEW,TH
申请号：
BR112018007128
公开号：
BR112018007128A2
申请日:
2016.10.10
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
The present invention relates to the quinoline and 5 of formula (I) for compound and epigenetics for inhibiting cancer, 6,7,8 tetrahydro acridines or its pharmaceutically acceptable form or prodrug, it is the inhibitor of such as transmethylase of protein lysine transmethylase colorectal cancer, and the inhibitor of more particularly SMYD3Wherein Z1、Z2、X、R1To R8It is defined as in the description with Y.Purposes the invention further relates to their preparation method, containing the pharmaceutical composition of these compounds and these compounds in treating the illness/patients condition/disease, illness/the patients condition/the disease is related to having the function of methyl transferase activity/and/or the enzyme via not specified/more targeting mechanism, related or related with the enzyme.
