There is provided a safety cabinet in which a good operability is attained and it is possible to secure a sterility assurance level. There is provided a safety cabinet including an operation chamber, a front door that covers part of an opening of a front surface of the operation chamber, an operation opening below the front door, into which an operator can insert an hand and perform an operation, and a front slit, which takes in air inside the operation chamber and air in a room through the operation opening, on a front surface side of a lower portion of the operation chamber, the cabinet including sterilization gas generating means； and sealing means for sealing the operation opening during a sterilization operation.
