Problem to be solved: to provide a safety cabinet capable of ensuring good workability and ensuring aseptic safety level.Working roomA front door covering a part of an opening in front of the working chamberBelow the front doorIt has a work opening that allows the operator to work with his handsOn the front side of the lower part of the working chamberA safety cabinet having a front slit for sucking air in the interior of the work chamber and the work opening through the working opening;Sterilization gas generating meansA sealing means is provided for sealing the work opening during the sterilization operation.作業性が良好で、かつ無菌性保証レベルを確保することができる安全キャビネットを提供する。 作業室と、前記作業室の前面の開口部の一部を覆う前面扉と、前記前面扉の下側に、作業者が手を入れて作業を行うことができる作業開口部を有し、前記作業室の下部の前面側に、作業室内の空気と前記作業開口部を通して部屋の空気を吸い込む前面スリットを備える安全キャビネットであって、滅菌ガス発生手段と、滅菌動作時に前記作業開口部を密閉する密閉手段を備えるものである。