The present invention relates compounds of Formula I’-III’, as well as their preparation and uses, and further relates pharmaceutical compositions comprising these compounds and their uses as nuclear transport modulators. The present invention also relates to uses of the compounds or pharmaceutical compositions in treating or preventing certain neurological disorders and diseases as well as certain types of cancer in humans.本發明關於式I’至III’化合物、彼等之製備和用途，且另關於包含該等化合物之醫藥組成物和該醫藥組成物作為核轉運調節劑之用途。本發明亦關於該等化合物或醫藥組成物於治療或預防人類的某些神經系統病症和疾病及某些癌症類型之用途。
