HERNANDEZ, Luis Alejandro,MUEHLENTHALER, Christine Margaret,VAUGHN, Eric Martin,HAIWICK, Gregory
申请号：
DK14789683
公开号：
DK3052516T3
申请日:
2014.10.02
申请国别(地区):
DK
年份:
2020
代理人:
摘要：
Vaccination methods to control PCV2 infection with different PCV2 subtypes are disclosed. Specifically, a PCV2 subtype b (PCV2b) ORF2 proteins or immunogenic compositions comprising a PCV2b ORF2 protein are used in a method for the treatment or prevention of an infection with PCV2 of the same PCV2b and/or different subtype； the reduction, prevention or treatment of clinical signs caused by an infection with PCV2 of the same PCV2b or a different subtype； and/or the prevention or treatment of a disease caused by an infection with PCV2 of the same PCV2b and/or a different subtype. The present invention in particular relates to PCV2 subtype b (PCV2b) ORF2 proteins characterized in that they contain at least one mutation in the BC loop that such that the expressed protein is preferably expressed in a higher amount compared to a PCV2 ORF2 protein that does not contain such mutation.
