Luis Alejandro Hernandez,Christine Margaret Muehlenthaler,Eric Martin Vaughn,Gregory Haiwick
申请号：
US15295053
公开号：
US10131696B2
申请日:
2016.10.17
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Vaccination methods to control PCV2 infection with different PCV2 subtypes are disclosed. Specifically, a PCV2 subtype b (PCV2b) ORF2 proteins or immunogenic compositions comprising a PCV2b ORF2 protein are used in a method for the treatment or prevention of an infection with PCV2 of the same PCV2b and/or different subtype； the reduction, prevention or treatment of clinical signs caused by an infection with PCV2 of the same PCV2b or a different subtype； and/or the prevention or treatment of a disease caused by an infection with PCV2 of the same PCV2b and/or a different subtype. The present invention in particular relates to PCV2 subtype b (PCV2b) ORF2 proteins characterized in that they contain at least one mutation in the BC loop that such that the expressed protein is preferably expressed in a higher amount compared to a PCV2 ORF2 protein that does not contain such mutation.
