BIOALVO - SERVIÇOS; INVESTIGAÇÃO E DESENVOLVIMENTO EM BIOTECNOLOGIA S.A.
发明人:
ANA DULCE ASCENSÃO CORREIA,CHRISTOPHE FRANÇOIS AIMÉ ROCA,EDUARDO BARDAJÍ RODRIGUEZ,HELENA MARGARIDA MOREIRA DE OLIVEIRA VIEIRA,JOSÉ MANUEL BERNARDO DE SOUZA,MANUEL NUNO DE SOUZA SIMÕES DE MEL,MARTA IS
申请号：
BRPI0911276
公开号：
BRPI0911276A2
申请日:
2009.04.01
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
The present invention relates to a compound of formula (I) wherein X is hydrogen, R1, R1C(O), R1CO2, or a COX2 inhibitor, wherein R1 is C1-20 alkyl, aryl, arylalkyl, alkyloxy or arylalkyloxy； wherein Y is OR2, NHR3N(R3)2, or a COX inhibitor； wherein R2 is hydrogen or C1-20 alkyl and each R3 is independently hydrogen or a C1-4 alkyl； wherein T is OR4, NHR5N(R5)2, or a COX inhibitor wherein R4 is hydrogen or C1-20 alkyl and each R5 is independently hydrogen or a C1-4 alkyl； wherein Z is hydrogen, R6, R6C(O), R6CO2, or a COX2 inhibitor； wherein R6 is C1-20 alkyl, aryl, arylalkyl, alkyloxy or arylalkyloxy； with the proviso wherein when X and Z are hydrogen and T is OH, Y is not OH； for use in the prevention and/or treatment of pain wherein said compound is provided for systemic administration.
