Sanjay Bhanot;Mark J. Graham;Kristina L. Lemonidis;Andrew T. Watt;Diane Tribble;Rosanne M. Crooke;Susan M. Freier
发明人:
Susan M. Freier,Rosanne M. Crooke,Mark J. Graham,Kristina L. Lemonidis,Sanjay Bhanot,Diane Tribble,Andrew T. Watt
申请号：
US13302070
公开号：
US08664190B2
申请日:
2011.11.22
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Disclosed herein are antisense compounds and methods for decreasing LDL-C in an individual having elevated LDL-C. Additionally disclosed are antisense compounds and methods for treating, preventing, or ameliorating hypercholesterolemia and/or atherosclerosis. Further disclosed are antisense compounds and methods for decreasing coronary heart disease risk. Such methods include administering to an individual in need of treatment an antisense compound targeted to a PCSK9 nucleic acid. The antisense compounds administered include gapmer antisense oligonucleotides.
