Susan M. Freier,Rosanne M. Crooke,Mark J. Graham,Kristina M. Lemonidis,Sanjay Bhanot,Andrew T. Watt,Diane Tribble
申请号：
US14152825
公开号：
US08912160B2
申请日:
2014.01.10
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Disclosed herein are antisense compounds and methods for decreasing LDL-C in an individual having elevated LDL-C. Additionally disclosed are antisense compounds and methods for treating, preventing, or ameliorating hypercholesterolemia and/or atherosclerosis. Further disclosed are antisense compounds and methods for decreasing coronary heart disease risk. Such methods include administering to an individual in need of treatment an antisense compound targeted to a PCSK9 nucleic acid. The antisense compounds administered include gapmer antisense oligonucleotides.
