Methods and systems are provided for multi-modality imaging. In one embodiment, a method comprises: during an ultrasound scan of a patient, co-aligning an ultrasound image received during the ultrasound scan with a three-dimensional (3D) image of the patient acquired with an imaging modality prior to the ultrasound scan； calculating an angle for an x-ray source based on position information in the 3D image to align the x-ray source with the ultrasound image； and adjusting a position of the x-ray source based on the calculated angle. In this way, the same internal views of a patient may be obtained with multiple modalities during an intervention with minimal user input.
