Nigel R. Stevenson,Jaime Simon,Gilbert R. Gonzales
申请号：
US15280062
公开号：
US20170014536A1
申请日:
2016.09.29
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Tin-117m somatostatin analogues or antagonist are used to treat tumors and symptoms associated with these tumors which express somatostatin receptors, such as gastroenteropancreatic neuroendocrine tumors. The tin-117m somatostatin receptor binding compounds can be administered at a dosage which is effectively apoptotic and not necrotic. Also, if desired, it can be administered at a dose that is necrotic and/or induces necrosis, but only to cells within 290 microns of the tin-117m atom. A novel somatostatin analogue is also disclosed, as well as novel methods to produce the tin labeled analogues and antagonists.
