Targeting Tumor Neovasculature with Modified Chimeric Antigen Receptors

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专利权人:

发明人:

Xiaoliu Zhang,Xinping Fu

申请号：

US14303769

公开号：

US20140369977A1

申请日:

2014.06.13

申请国别(地区):

US

年份:

2014

代理人:

摘要：

A T cell transduced with a chimeric antigen receptor can be administered to a host to kill cancer cells. The chimeric antigen receptor can include a targeting moiety with a strong binding affinity to αvβ3 integrin, including but not limited to an echistatin polypeptide. The targeting moiety can also be modified to have a reduced binding affinity to α5β1 integrin.

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中国工程科技知识中心

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http://www.ckcest.cn/home/