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Method and thermal conductivity detector
专利权人:
Siemens Aktiengesellschaft
发明人:
Gellert Udo,Schmidt Glen Eugene
申请号:
US201615151069
公开号:
US10126277(B2)
申请日:
2016.05.10
申请国别(地区):
美国
年份:
2018
代理人:
Cozen O'Connor
摘要:
A thermal conductivity detector includes a heatable resistive detector configured to be physically arranged in an analytes flow eluting from a chromatography column and electrically arranged with resistors in separate arms of a measuring bridge, an amplifier which detects differential voltage between two opposite nodes of the bridge and applies an output voltage to other opposite nodes of the measuring bridge to maintain the detector at a constant operating temperature, and an additional resistor with a controllable switch in parallel connected in series with the detector or resistor arranged in one arm of the bridge, where the switch is periodically turned on and off at a predetermined duty cycle and/or controlled by information on characteristic times-of-arrival of analytes at the detector to compensate for operating temperature uncertainties due to manufacturing variations of the resistors and/or to allow for processing small and large peaks of a chromatogram with highest available resolution.
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