The present disclosure discloses a pharmaceutical composition for treating menopausal mental depression and atypical depressive disorder and an application thereof. The composition is composed of the following components in percentage by mass: 70%-97.5% of sea buckthorn pulp oil and 2.5%-30% of total panax notoginseng saponins from stem and leave. The application is use of the pharmaceutical composition for preparing drugs and/or health care products used for treating menopause, the menopausal mental depression or the atypical depressive disorder.
