The invention relates to a new compound as a rearrangement kinase inhibitor in the process of transfer.Pharmaceutical compositions containing them, their preparation methods, and their use in the normalization of gastrointestinal sensitivity in single or combination therapy, Sports and / or secretory and / or abdominal diseases or disorders and / or diseases related to ret dysfunction or RET dysfunction, in which the regulation of RET activity has therapeutic advantages, and the regulation of RET activity not only includes all categories of colon syndrome Especially IBS with diarrhea, major constipation, diarrhea and constipation,Functional air bag, functional constipation, functional diarrheaFunctional abdominal pain syndrome, chronic spontaneous constipation, functional esophageal disease, functional gastroduodenal disease, functional positive rectal pain, inflammatory abdominal pain, proliferative diseases such as ` non-small cell bronchogenic carcinoma ', HCC, rectal cancer, medullary thyroid cancer, follicular thyroid cancer, adrenal thyroid cancer, breast thyroid cancer, brain tumor, peritoneal cavity cancer, solid tumor, other lung cancer, Head and neck cancerGlycoma, neurocytoma, von Hippel Lindau syndrome and renal tumor, breast cancer, fallopian tube cancer, ovarian cancer, transitional cell cancer, prostate cancer, esophageal cancer and gastroesophageal colon cancer, cholangiocarcinoma, adenocarcinoma, And any malignancy with increased RET kinase activity.La présente invention concerne de nouveaux composés qui sont des inhibiteurs de la kinase réarrangée au cours de la transfection (ret), des compositions pharmaceutiques contenant ceux-ci, des procédés pour leur préparation, et leur utilisation en thérapie, seuls ou en association, pour la normalisation de la sensibilité gastrointestinale, la motilité et/ou la sécrétion et/ou des troubles ou maladies abdominales et/ou dans le traitement de maladies associées à un dysfonctionnement de la ret ou des maladie
