FUNDACION HOSPITAL NACIONAL DE PARAPLEJICOS PARA LA INVESTIGACION Y LA INTEGRACION;UNIVERSIDAD DE CASTILLA LA MANCHA
发明人:
COLLAZOS CASTRO, JORGE EDUARDO,POLO SANZ, JOSÉ LUIS,HERNANDEZ LABRADO, GABRIEL RAÚL,GARCIA RAMA PACHECO, CONCEPCIÓN
申请号：
ES201231969
公开号：
ES2470495A1
申请日:
2012.12.19
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
The invention consists of compositions, methods and devices for inducing, stimulating and directing the adhesion, proliferation and migration of neural precursors and axonal and dendritic growth. The invention comprises electroconductive substrates in the form of microfibres or surfaces that are biofunctionalised so as to include one or more biomolecules of interest in order to control cell behaviour. Said substrates can be used for neurobiological studies, cell cultures and pharmagological assays in vitro, and can be implanted in the nervous system in the form of electro-biological devices or scaffolds, in order to promote neural tissue repair or to improve communication in the electrode/neural cell interface in neuroprosthetic systems. The cellular effects are obtained by the type, number and type of bond between the molecules and the substrates, by the physical properties of same and the shape of the scaffolds, by electrical stimulation or by the combined effect of these factors.Materiales, m�todos y dispositivos para estimular y dirigir la proliferaci�n y migraci�n de progenitores neurales y el crecimiento axonal y dendr�tico.#La presente invenci�n consiste en composiciones, m�todos y dispositivos para inducir, estimular y dirigir la adherencia, proliferaci�n y migraci�n de precursores neurales y el crecimiento axonal y dendr�tico. Comprende sustratos electroconductores en forma de superficies o microfibras biofuncionalizadas para presentar una o varias biomol�culas de inter�s con el fin de controlar el comportamiento celular. Estos sustratos pueden utilizarse para estudios neurobiol�gicos, cultivos celulares y ensayos farmacol�gicos in vitro； as� como para implantarse en el sistema nervioso en forma de andamios o dispositivos electrobiol�gicos, con el fin de promover la reparaci�n del tejido neural o de mejorar la comunicaci�n en la interfaz electrodo/c�lula neural en sistemas neuroprot�sicos. Los efectos celulares se consi
