Trpv1 antagonists including dihydroxy substituent and uses thereof

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专利权人:

SHIONOGI & CO. LTD.

发明人:

TAFESSE LAYKEA,ANDO SHIGERU,KUROSE NORIYUKI

申请号：

NZ61891212

公开号：

NZ618912A

申请日:

2012.06.21

申请国别(地区):

NZ

年份:

2015

代理人:

摘要：

Provided are N-(benzo[d]thiazol-2-yl)-4-{ 5-[1,2-dihydroxyethyl]-3-halo/trifluoromethylpyridin-2-yl} -piperazin-1-yl-carboxamide derivative compounds of the general formula (I), wherein the variables are as defined in the specification. An example of the compounds is (5)-4-{ 5-[(5)-1,2-Dihydroxyethyl]-3-fluoropyridin-2-y1)-N-(5-fluorobenzo[d]thiazol-2-y1)- 2-methylpiperazine-1-carboxamide. The compounds are antagonists of Transient Receptor Potential Vanilloid 1 (TRPV1). The compounds may be useful in the treatment of pain, osteoarthritis, urinary incontinence, ulcers, inflammatory bowel diseases (IBDs) and irritable bowel syndrome (IBS).

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