PURPOSE: A method for selecting a subject to be treated with obesity therapy is provided to accurately select the subject among a candidate group with various genetic and environmental differences. CONSTITUTION: A method for selecting a subject to be treated with obesity therapy using a therapeutic agent for obesity comprises: a step of measuring the amount of hypoxanthine in a biological sample and a step of comparing hypoxanthine amount with the amount of a control group. The biological sample is blood, serum, plasma, lymph, urine, feces, semen, or amniotic fluid. A composition for selecting the subject for the therapeutic agent for obesity contains hypoxanthine binder or enzyme.본 발명은 비만 치료 대상을 선별하는 방법 및 비만 치료제에 대한 비만 치료 대상을 선별하기 위한 조성물에 관한 것이다.본 발명은 바이오마커로서 하이포잔틴을 사용하여 다양한 유전적, 환경적 차이를 지닌 치료 대상 후보군으로부터 비만 치료 대상체를 정확하게 선별할 수 있다.