A respiratory therapy system that includes a gas delivery device enabled to deliver a quantity of oxygen-enriched gas and a quantity of insufflation gas is disclosed. The respiratory therapy system further provides a transtracheal catheter coupled to the gas delivery device. Additionally, the gas delivery device is enabled to deliver the quantity of insufflation gas during a first portion of a breathing cycle of a patient and to deliver the quantity of oxygen-enriched gas during a second portion of the breathing cycle.