A novel protein binding to osteoclastogenesis inhibitory factor (OCIF) (OCIF-binding molecule; OBM). A DNA encoding the above protein; a protein having theamino acid sequence encoded by this DNA; a process for producing this proteinby the genetic engineering technique; and medicinal compositions containingthis protein. A method for screening a substance regulating the expression ofthe above protein, a substance inhibiting or modifying the biological activityof the above protein, or a receptor binding to the above protein and thusmediating its function with the use of the above protein and the DNA thereof;substances thus obtained; and medicinal compositions containing the substancesthus obtained. An antibody against the above protein; a method for assayingthe above protein by using the antibody; and drugs containing the antibody.