Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.特定經取代之脲衍生物選擇性地調節心肌原纖維節(例如利用增強心肌球蛋白),可用於治療包括充血性心臟衰竭之收縮性心臟衰竭。