The present invention relates to a connection arrangement and a method of assembly, for providing a substantially tamper resistant connection with at least a first medical device. The connection arrangement (1) having a centre axis (A),the connection arrangement (1) comprises a first connection member (21,161,521,621) for connection to the first medical device by means of a rotational motion in a first direction, and a body (60,120, 504, 603). Additionally the first connection member (21,161,521,621) and the body (60,120, 504, 603) are connected directly or indirectly together via at least one designated ruptureable retaining member (41, 141, 541, 641), the designated ruptureable retaining member (41, 141, 541, 641) is arranged to rupture at a predetermined breaking force, wherein the first connection member (21,161,521,621), and thereby the first medical device after assembly, can be displaced with respect to the body (60,120, 504, 603) after rupture. The present invention provides for a substantially tamper safe connection arrangement which disables accidents such as wrongly disengage a connected medical device. A safer handling is provided for the involved user(s).
