FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to compounds of formula I wherein R means C1-6alkyl, C1-6halogenalkyl, hydroxy-C1-6alkyl, hydroxygroup or halogen； m, n is equal to 0 or 1； Z1 means CH or NH； Z2 means CH or N； Z3 means CR1, N or NR2； R1 means H, C1-6alkyl, C3-7cycloalkyl, cyanogroup, cyano-C1-6alkyl or halogen； R2 means H or C1-6alkyl； X means CH, CR' or N； X' means CH, CR' or N； r is equal to 1； Y means CH or CR'； R' means R'a or R'b； R'a means a halogen or cyanogroup； R'b means C1-6alkyl, heterocycloalkyl specified in piperazinyl, morpholinyl, piperidinyl, thiomorpholinyl, azetidinyl, pyrrolidinyl, OR", SR", S(=O)2R" or NR"R", optionally substituted by one or more R'c； R'c means a hydroxygroup, oxogroup, cyanogroup, C1-6alkyl, pyridinyl, carboxy-C1-6alkyl, aminocarbonyl-C1-6alkylaminogroup, C1-6alkylaminogroup, C1-6dialkylaminogroup or C1-6alkoxygroup； R" means H, C1-6alkyl, hydroxy-C1-6alkyl, piperidinyl, C3-7cycloalkyl or pyridinyl； Q means S(=O)2Q1, C(=O)Q2, C(=O)OQ3 or Q4； Q1 means C1-6alkyl, C3-7cycloalkyl-C1-6alkyl, C1-6alkylaminogroup or C1-6dialkylaminogroup optionally substituted by one or more Q1'； each Q1' independently means C1-6alkyl or cyanogroup； Q2 means C1-6alkyl optionally substituted by one or more Q2'； each Q2' independently means a cyanogroup； Q3 means C1-6alkyl； Q4 means C1-6alkyl, oxetanyl optionally substituted by one or more Q4'； each Q4' independently means a halogen, cyanogroup, cyano-C1-6alkyl； p is equal to 0, 1 or 2； q is equal to 1 or 2； each means a single bond or a double bond； provided one of Z1 and Z2, and Z3 and Z3 bonds are double and single.EFFECT: compounds of formula I as JAK inhibitors.23 cl, 2 tbl, 121 exИзобретение относится к соединениям формулы I, в которой R обозначает C1-6алкил, C1-6галогеналкил, гидрокси-C1-6алкил, гидроксигруппу или галоген； m, n равно 0 или 1； Z1 обозначает CH или NH； Z2 обозначает CH или N； Z3 обозначает CR1, N или NR2； R1 обозначает H, C1-6алкил, C3-7циклоалкил, циан
