PHARMACEUTICAL COMPOSITION COMPRISING ETHANOL EXTRACTS OF SEEDPOD OF NELUMBO NUCIFERA AS AN EFFECTIVE COMPONENT FOR PREVENTION OR TREATMENT OF THROMBOSIS AND HEALTH FUNCTIONAL FOOD COMPRISING THE SAME
안동대학교 산학협력단;ANDONG NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
发明人:
손호용,SOHN HO YONG
申请号：
KR1020200001185
公开号：
KR1020200004460A
申请日:
2020.01.06
申请国别(地区):
KR
年份:
2020
代理人:
摘要：
The present invention relates to a pharmaceutical composition and health functional food for preventing or treating thrombosis (Seedpod of Nelumbo nucifera ) containing ethanol extract as an active ingredient, more specifically, the ethanol extract yeonjabbang, The present invention relates to a pharmaceutical composition and a health functional food for preventing or treating / improving thrombosis through strong platelet aggregation inhibition and blood coagulation inhibition containing organic solvent fraction or water residue after fractionation as an active ingredient. Inhibitory effect of platelet aggregation to inhibit the thrombosis-producing enzyme and blood coagulation factor in combination with the inhibition of thrombosis-related enzymes and blood coagulation factors It exhibits strong antithrombotic activity and no hemolytic activity against human erythrocytes, excellent thermal stability, loss of blood coagulation factor inhibitory effect and thrombus formation related enzyme inhibitory effect even in acidic conditions and plasma of pH 2 Since it does not appear, it is expected to be used as a pharmaceutical composition and health functional food for the prevention and treatment / improvement of thrombosis such as ischemic stroke and hemorrhagic stroke through the improvement of blood circulation, and the active ingredient is extract, powder, pill, tablet It can be processed into various forms such as It is a very useful invention in the pharmaceutical and food industry because it has an excellent effect.본 발명은 연자방(Seedpod of Nelumbo nucifera) 에탄올 추출물을 유효성분으로 함유하는 혈전증(thrombosis)의 예방 또는 치료용 약학적 조성물 및 건강 기능 식품에 관한 것으로서, 보다 구체적으로는, 연자방 에탄올 추출물, 상기 추출물의 유기 용매 분획물 또는 분획 후의 물 잔류물을 유효성분으로 함유하는 강력한 혈소판 응집 저해 및 혈액 응고 저해를 통한 혈전증의 예방 또는 치료/개선용 약학적 조성물 및 건강 기능 식품에 관한 것이다. 본 발명의 혈전증의 예방 또는 치료용 약학적 조성물 및 건강 기능 식품의 유효성분으로서의 연자방 에탄올 추출물은 혈전 생성 관련 효소 및 혈액 응고 인자의 저해와 함께 혈전 생성의 개시 역할을 수행하는 혈소판의 응집 저해 효과에 의한 강력한 항혈전 활성을 나타냄과 동시에, 인간 적혈구에 대한 용혈 활성을 전혀 나타내지 않고, 열 안정성이 우수하고,
