YAGODICH MARY K,CITRON MICHAEL P,DISTEFANO DANIEL J,KRAH DAVID L,LIANG XIAOPING
申请号：
CO11058596
公开号：
CO6362047A2
申请日:
2011.05.12
申请国别(地区):
CO
年份:
2012
代理人:
摘要：
A Live Attenuated Respiratory syncytial virus (RSV) comprising a viral GenomeWhere The Viral Genome encodes Proteins that include one or more amino acids selected from the group consisting of: a glutamic acid at position 204 of the Protein encoded by the Gene g； a glutamic acid at position 205 of the Protein encoded by the gene (g； Alanine at position 21 Protein encoded by the Gene g； a glutamic acid at position 213 of theProtein encoded by the Gene g； Glycine at position 221 of the Protein encoded by the Gene g； a glutamic acid at position 223 of the Protein encoded by the Gene g； Glycine at position 232 of the Protein encoded by the Gene g； a lysine at position 294 of the Protein encoded by the gene (F； a Glycine at position 486 of the Protein encoded by the gene a to F；LANINA at position 148 of the Protein encoded by the gene l； and a phenylalanine in 2054, the position of the Protein encoded by the Gene.- attenuated RSV of claim 1, wherein the viral Genome encodes Proteins that comprise a lysine at position 294 of the Protein encoded by the Gene F, a Glycine at position 486 of the Protein encoded by the Gene F, an alanine at position 148 Protein Cod The ificada gene l, 2054 and phenylalanine in the position of the Protein encoded by the Gene.- attenuated RSV of claim 2, wherein the Protein coded by the Gene F and L amino u00e1cidas include sequences that are at least 95% identical to the sequences amino u00e1cidas as disclosed in SEQ ID no: SEQ ID no: 18 and 24, respectivelyUn virus sincitial respiratorio vivo atenuado (VSR) que comprende un genoma viral, en donde el genoma viral codifica proteínas que comprenden uno o más aminoácidos seleccionados a partir del grupo que consta de: un ácido glutámico en la posición 204 de la proteína codificada por el gen G； un ácido glutámico en la posición 205 de la proteína codificada por el gen G； una alanina en la posición 21 de la proteína codificada por el gen G； un ácido glutámico en la posición 213 de la proteína codifi
