Provided is a novel therapeutic agent for chronic obstructive pulmonary disease.Provided are a quinuclidine derivative and a medicament comprising the quinuclidine derivative.wherein R1 represents a hydrogen atom, a halogen atom, a lower alkyl group, a haloalkyl group, a lower alkoxy group, or a haloalkoxy group； Y represents -C(C=O)-O-, -CH2-, or -CH2O-； m represents an integer of 1 to 5； Z represents an oxygen atom or a sulfur atom； l represents a number of 0 or l； n represents an integer of 0 to 4 ； X- represents an anion； and a substituent of a quinuclidine ring represents a 1,3-bond, or 1,4-bond, provided that when m is 3, l is 1, and n is 0, R1 represents a halogen atom, a lower alkyl group, a haloalkyl group, a lower alkoxy group, or a haloalkoxy group.
