Provided is a new agent for treating chronic obstructive pulmonary disease. The present invention provides quinuclidine derivatives represented by general formula (1), and a pharmaceutical containing the same. (In the formula, R1 indicates a hydrogen atom, halogen atom, lower alkyl group, haloalkyl group, lower alkoxy group, or haloalkoxy group； Y indicates -C(C=O)-O-, -CH2-, or -CH2O-； m indicates an integer of 1-5； Z indicates an oxygen atom or sulfur atom； l indicates 0 or 1； n indicates an integer of 0-4； X- indicates an anion； and the substituent of the quinuclidine ring indicates a 1,3-bond or 1,4-bond. However, when m is 3, l is 1, and n is 0, R1 indicates a halogen atom, lower alkyl group, haloalkyl group, lower alkoxy group, or haloalkoxy group.)
