Institute of Materia Medica; Chinese Academy of Medical Sciences
发明人:
Yuling Liu,Cuiping Zhou,Zhihui Song,Lin Li,Hongliang Wang,Xuejun Xia,Renyun Wang,Wujun Dong,Dujia Jin
申请号:
US15895282
公开号:
US10611852B2
申请日:
2018.02.13
申请国别(地区):
US
年份:
2020
代理人:
摘要:
Provided are an insulin-lipid complex, a preparation method thereof, and a formulation thereof. The insulin-lipid complex is prepared by compounding insulin and a lipid material in an organic solvent system containing a low boiling point acid, and drying. The mass ratio of insulin to the lipid material is 1:3˜1:20. An oil solution of the insulin-lipid complex and vesicles containing insulin are further provided.