BENZISOTHIAZOLE, ISOTHIAZOLO[3,4-B]PYRIDINE, QUINAZOLINE, PHTHALAZINE, PYRIDO[2,3-D]PYRIDAZINE AND PYRIDO[2,3-D]PYRIMIDINE DERIVATIVES AS KRAS G12C INHIBITORS FOR TREATING LUNG, PANCREATIC OR COLORECTAL CANCER
YANG, Kevin C.,ASHTON, Kate,BOOKER, Shon,LANMAN, Brian, Alan,PICKRELL, Alexander J.,KOPECKY David John,WANG,Hui-Ling,LOPEZ, Patricia,TEGLEY, Christopher M.,CEE, Victor J.,REED Anthony B.
申请号：
CR20190338
公开号：
CR20190338A
申请日:
2017.12.21
申请国别(地区):
CR
年份:
2019
代理人:
摘要：
1. The existing benzodiazepine, isodiazole [3,4-b] pyridine, quinazol, zinc phthalate, pyridine [2,3-d] pyridine and pyridine derivative [2,3-d] pyridine, as well as related compounds as G12C KRAS inhibitors, can be used in the treatment of lung cancer, pancreatic cancer or rectal cancer. Pyridine derivatives and related compounds as KRAS G12C investors for treating e.g. lung cancer, pancreatic cancer or Colline cancerSe proporcionan en la presente benzoisotiazol, isotiazolo[3,4-b]piridina, quinazolina, ftalazina, pirido[2,3-d]piridazina y derivados de pirido[2,3-d]pirimidina y compuestos relacionado como inhibidores de KRAS G12C para tratar, por ejemplo, el cáncer de pulmón, cáncer pancreático o cáncer colorrectal.Provided herein are benzisothiazol, isothiazolo[3,4-b]pyridine, quinazoline, phthalazine, pyrido[2,3-d]pyridazine and pyrido[2,3-d]pyrimidine derivatives and related compounds as KRAS G12C inhibitors for treating e.g. lung cancer, pancreatic cancer or colorectal cancer.
