The preparation of 4 β of anti alpha, 7 antibody农业专利-农业学术服务平台

发明人:: DILUZIO, WILLOW,威尔洛．迪卢齐奥,威爾洛．迪盧齊奧,NGUYEN, PHUONG M.,方．M．源,VARGA, CSANAD M.,乔纳德．M．瓦尔加,喬納德．M．瓦爾加,PALANIAPPAN, VAITHIANATHAN,维斯阿纳桑．帕拉尼阿帕安,維斯阿納桑．帕拉尼阿帕安,BROWN, JASON,贾森．布朗,賈森．布朗,FOX, IRVING H,欧文．H．福克

摘要：: The antibody preparation of mixture of the present invention description comprising 4 β of anti alpha, 7 antibody, antioxidant or chelating agent and at least one free amino acid. Disclosed preparation can have the stability of raising, the aggregation of reduction is formed or both. The safe administration scheme of 4 β of the anti alpha, 7 antibody of therapeutically effective amount is followed and generated in vivo the present invention further provides a kind of easy what of these antibody preparations.本發明描述包含抗α4β7抗體、抗氧化劑或螯合劑和至少一種游離氨基酸的混合物的抗體製劑。公開的製劑可具有提高的穩定性、減少的聚集體形成或其兩者。本發明進一步提供這些抗體製劑的一種易於遵循且在體內産生治療有效量的所述抗α4β7抗體的安全給藥方案。