Burak, Eric Steven,Forbes, John Richard,Moran, Matthew David Burr,Simms, Ryan Wayne,Valliant, John Fitzmaurice
申请号：
AU2018261890
公开号：
AU2018261890A1
申请日:
2018.05.04
申请国别(地区):
AU
年份:
2019
代理人:
摘要：
The present invention relates to conjugates including a chelating moiety of a metal complex thereof and a therapeutic or targeting moiety, methods for their production, and uses thereof. The present invention is directed to monoclonal antibodies that target the insulin-like growth factor-1 receptor and the radioimmunoconjugates thereof that demonstrate increased potency and enhance the excretion of a chelating moiety, or a metal complex thereof, when conjugated to a therapeutic moiety, a targeting moiety, or a cross-linking group. In another aspect, the invention features a pharmaceutical composition comprising a compound of the invention； and a pharmaceutically acceptable excipient. In another aspect, the invention features a method of radiation treatment planning and/or radiation treatment, the method comprising administering to a subject in need thereof a compound or pharmaceutical composition of the invention.
