2,4 DIAMINO-QUINOLINE SUBSTITUÉE EN TANT QUE NOUVEAU MÉDICAMENT DESTINÉ À LA FIBROSE, L'AUTOPHAGIE ET DES MALADIES LIÉES AUX CATHEPSINES B (CTSB), L (CTSL) ET D (CTSD)
The present invention relates to novel 2-primary amino-4-secondary amino-quinoline derivatives, their manufacture, pharmaceutical compositions comprising them and their use as medicaments. The active compounds of the present invention can be useful as a medicament in the treatment and/or the decreasing and/or the prevention of fibrosis and/or fibrosis related diseases, or for use as a medicament in the treatment and/or the decreasing and/or the prevention of the autophagy and/or autophagy related diseases and for the inhibition of the autophagy flux, or for use in the inhibition of cathepsins B (CTSB), L (CTSL) and/or D (CTSD) and/or cathepsins B (CTSB), L (CTSL) and/or D (CTSD) related diseases； with the proviso that said compounds are not to be used for the treatment of any forms of cancers.
