composition for releasing a polynucleotide in a cell, method for releasing a polynucleotide, and method for reducing or preventing expression of a gene in a cell
HER MAJESTY THE QUEEN IN RIGHT OF CANADA; AS REPRESENTED BY THE MINISTER OF AGRICULTURE AND AGRI-FOOD
发明人:
FRANÇOIS EUDES,JORDAN PEPPER
申请号：
BR112018069424
公开号：
BR112018069424A2
申请日:
2017.03.23
申请国别(地区):
BR
年份:
2019
代理人:
摘要：
Compositions including a polynucleotide nano complex with a cell penetrating peptide and a quaternary phosphonium salt, such as tetrabutylphosphonium bromide (tbpb), are useful for the release of polynucleotides such as dna or rna into cells.composições incluindo um nano complexo de um polinucleotídeo com um peptídeo de célula-penetrante e um sal de fosfônio quaternário, tal como brometo de tetrabutilfosfônio (tbpb), são úteis para a liberação de polinucleotídeos, tais como dna ou rna em células.
