The present disclosure provides cytidine derivative dimers, salts andcompositions of thecytidine derivative dimers, and methods of making and using the cytidinederivative dimersthat are useful for treating a neoplasm in mammalian subjects. A cytidinederivative dimermay have the following general formula (I):By molecularly designing such cytidine-based compounds, the disclosed cytidine-basedderivative dimers/salts show significant inhibiting effects on HCT-116 humancolon cancercells, and exhibit strong growth inhibiting effects on HCT-116 human coloncancerxenografts grown in nude mice. The disclosed cytidine derivative dimers/saltsprovide highanti-tumor activity with low toxicity and are useful for treating cancers.(see above formula)
