HIGH AFFINITY AND AGGREGATIVELY STABLE ANTIBODIES ON THE BASIS OF VAIRABLE DOMAIN VL AND A DERIVATIVE VHH

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专利权人:

CLOSED JOINT STOCK COMPANY "BIOCAD"

发明人:

ULITIN, ANDREY BORISOVICH,EVDOKIMOV, STANISLAV RUDOLFOVICH,SOLOVIEV, VALERIY VLADIMIROVICH,CHERNYH, YULIA SERGEEVNA,GONCHAROVA, OLGA VLADIMIROVNA,KORZHAVIN, DMITRIY VALERIEVICH,CHERNOVSKAYA, TATYANA V

申请号：

PH12016501391

公开号：

PH12016501391A1

申请日:

2016.07.14

申请国别(地区):

PH

年份:

2016

代理人:

摘要：

What are proposed are: monoclonal antibodies of the type IgG comprising variable domains in the form of a combination of a derivative VHH with a variable domain of a light chain VL. The antibodies mentioned may comprise amino acid substitutions in positions 44 and/or 45 (according to the Kabat numbering scheme) or combinations thereof. The antibodies described have increased affinity and improved aggregation stability.

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