High affinity and aggregatively stable antibodies on the basis of variable domains vl and a derivative vhh

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专利权人:

CLOSED JOINT STOCK COMPANY “BIOCAD”

发明人:

Ulitin, Andrey Borisovich,Evdokimov, Stanislav Rudolfovich,Soloviev, Valeriy Vladimirovich,Chernyh, Yulia Sergeevna,Goncharova, Olga Vladimirovna,Korzhavin, Dmitriy Valerievich,Chernovskaya, Tatyana V

申请号：

NZ72430615

公开号：

NZ724306A

申请日:

2015.03.23

申请国别(地区):

NZ

年份:

2018

代理人:

摘要：

What are proposed are: monoclonal antibodies of the type IgG comprising variable domains in the form of a combination of a derivative VHH with a variable domain of a light chain VL. The antibodies mentioned may comprise amino acid substitutions in positions 44 and/or 45 (according to the Kabat numbering scheme) or combinations thereof. The antibodies described have increased affinity and improved aggregation stability.

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