It refers to the compound produced from the formula of 2-amino-6 (fluoromethyl) - 5, 5-fluoro-6-phenyl-3, 4, 5, 6-tetrahydropyridine (I) with Ar as phenyl, pyridyl and other substitutes； R1 is h, halogen, etc. It is a selected compound (s) - N - (3 - (6-amino-2 - (difluoromethyl) - 3, 3, 3, 4, 5-tetrahydropyridine-2-il) - 4-fluorophenyl) - 5-chloropyridine, etc. He also mentioned a pharmacologist who had it These compounds are effective means of inhibiting the enzyme bae1, and can be used to treat diseases that are beneficial due to the reduction of ammonia deposition, such as Alzheimer's disease.Se refiere a compuestos derivados de 2-amino-6-(difluorometil)-5,5-difluoro-6-fenil-3,4,5,6-tetrahidropiridinas de formula (I) donde Ar es fenilo, piridilo, entre otros opcionalmente sustituido； R1 es H, halogeno, entre otros. Es un compuesto seleccionado (S)-N-(3-(6-amino-2-(difluorometil)-3,3-difluoro-2,3,4,5-tetrahidropiridin-2-il)-4-fluorofenil)-5-cloropicolinamida； entre otros. Tambien se refiere a una composicion farmaceutica que la contiene. Dichos compuestos son inhibidores de la enzima beta-secretasa 1 (BACE1) siendo utiles para tratar trastornos para los cuales la reduccion de depositos de beta-amiloides es beneficioso, tal como la enfermedad de Alzheimer
