FAIRHURST, ROBIN ALEC,FURET, PASCAL,KALTHOFF, FRANK STEPHAN,LERCHNER, ANDREAS,RUEEGER, HEINRICH
申请号：
PE0006152015
公开号：
PE10062015A1
申请日:
2013.11.11
申请国别(地区):
PE
年份:
2015
代理人:
摘要：
The Invention relates to compounds of oxazolidin ONA - 2 - substituted pyrimidine of formula (i), which act as inhibitors of the PI3K (phosphatidylinositol 3-kinase), as well as pharmaceutical compositions thereof, Methods for their manufacture and use for the treatment of conditions S, diseases, and disorders of the PI3K dependent.Preferred compounds are: (4S, 5R) - 3 - (2 - amino - 4 - 2 (IL - 4 - trifluoromethyl - [4,5] bipirimidinil - 6 - yl) - 4 - methyl - 5 - thiazol-2-yl - oxazolidin - ona (4 * 2 *, 5S) - 3 - (2 - amino - 2 - morpholino - 4 - (trifluoromethyl) - [4,5] - 6 - bipirimidin - yl) - ethyl - 4 - 5 - (4-methoxyphenyl) oxazolidin - 2 - One among othersLa invencion se relaciona con compuestos de pirimidina oxazolidin-2-ona sustituidos de formula (I), que actuan como inhibidores de la PI3K (fosfatidilinositol-3-quinasa), asi como tambien composiciones farmaceuticas de los mismos, metodos para su fabricacion y usos para el tratamiento de condiciones, enfermedades y trastornos dependientes de la PI3K. Los compuestos preferidos son: (4S,5R)-3-(2-amino-2-morfolin-4-il-4-trifluorometilo-[4,5]bipirimidinil-6-il)-4-metil-5-tiazol-2-il-oxazolidin-2-ona (4S*,5S*)-3-(2-amino-2-morfolino-4-(trifluorometil)-[4,5-bipirimidin]-6-il)-4-etil-5-(4-metoxifenil)oxazolidin- 2- ona entre otros
