The invention relates to a packaging system (1, 20) of two or more objects or containers (2) in a controlled environment, able to contain a first container (1), equipped with a barrier of sterility, and a casing or package (20), externally coupled to the first container (1) and provided with at least one removable wall (8), so that said container (1) can be accessible from outside and/or can be decoupled from said casing or package (20).