부산대학교 산학협력단;PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION;MOGAM BIOTECHNOLOGY RESEARCH INSTITUTE;목암생명공학연구소
发明人:
LEE, Bok Luel,이복률,KENJI, Kurokawa,켄지쿠로카와,JUNG, Dong-Jun,정동준,AN, Jang-Hyun,안장현,JEON, Yu-Jin,전유진,KIM, Na Hyang,김나향,KAZUE, Takahashi,카주에타카하시,KIM, Eunmi,김은미,AHN, Dong Ho,안동호
申请号：
KRKR2013/003957
公开号：
WO2013/168965A3
申请日:
2013.05.07
申请国别(地区):
KR
年份:
2014
代理人:
摘要：
The present invention relates to a vaccine composition for preventing staphylococcus aureus infection containing, as an active ingredient, a ribitol-phosphate which has been modified only by a β-configuration in N-Acetylglucosamine (GlcNAc), a repeating unit of the ribitol-phosphate, or a wall teichoic acid (WTA) containing the repeating unit. The composition according to the present invention contains a coupling motif (an epitope) for an anti-WTA antibody, and thus can be effectively used as a vaccine composition or to prevent staphylococcus aureus infection by generating anti-WTA antibody.La présente invention concerne une composition de vaccin pour prévenir une infection par Staphylococcus aureus contenant, comme principe actif, un ribitol-phosphate qui a été modifié seulement par une configuration β dans la N-acétylglucosamine (GlcNAc), une unité répétitive du ribitol-phosphate, ou un acide téichoïque de paroi (WTA) contenant l'unité répétitive. La composition selon la présente invention contient un motif de couplage (un épitope) pour un anticorps anti-WTA, et ainsi peut être utilisée efficacement comme composition de vaccin ou pour prévenir une infection par Staphylococcus aureus par la génération d'anticorps anti-WTA.본 발명은 N-아세틸글루코사민(GlcNAc)이 β-위치(β-configuration)로만 수식된 리비톨-인산염 또는 이의 반복 단위, 또는 상기 반복 단위를 포함하는 벽테이코산(WTA)을 유효성분으로 함유하는, 포도상구균 감염 예방용 백신 조성물에 관한 것으로서, 본 발명의 조성물은 항-WTA 항체에 대한 결합 모티프(에피토프)를 함유하므로 백신 조성물로서 또는 항-WTA 항체를 생산하여 포도상구균 감염을 예방하는 용도로서 유용하게 사용될 수 있다.
