Heather Elizabeth Burks,Michael A. Dechantsreiter,Guo He,Jill Nunez,Stefan Peukert,Clayton Springer,Yingchuan Sun,Noel Marie-France Thomsen,George Scott Tria,Bing Yu
申请号：
US15898561
公开号：
US10058534B2
申请日:
2018.02.17
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to compounds of formula I:in which n, m, X, Y1, R1, R2, R3, R4 and R5 are defined in the Summary of the Invention； capable of being both potent antagonists and degraders of estrogen receptors. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with aberrant estrogen receptor activity.
