Covalent binding of ligands to nucleophilic proteins induced by non-covalent bonds

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专利权人:

西山 泰弘;ポール,サッドヒル;ポール，サッドヒル

发明人:

ポール，サッドヒル,西山 泰弘,ポール,サッドヒル

申请号：

JP2006509376

公开号：

JP5503837B2

申请日:

2004.03.26

申请国别(地区):

JP

年份:

2014

代理人:

摘要：

A covalently reactive ligand analogue (CAL) of formula (1): wherein, L1 . . . Lx . . . Lm are components defining a ligand determinant, Lx is a component unit of the ligand determinant selected from the group consisting of an amino acid residue, sugar residue, a fatty acid residue and a nucleotide, L&prime； is a functional group of Lx, Y&Prime； is atom, covalent bond or linker, Y&prime； is an optional charged or neutral group Y is a covalently reactive electrophilic group that reacts specifically with a receptor that binds to said ligand determinant, and n is an integer from 1 to 1000 m is an integer from 1 to 30.

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