Novel pyrimidine derivatives of formula (I) and their use for the manufacture of a medicament for the treatment or prevention of a disease which responds to inhibition of FAK and/or ALK and/or ZAP-70 and/or IGF-IR. in which: n' is selected from 1,2 and 3; R' 1 is selected from phenyl, pyridinyl, pyrazolyl and pyrimidinyl; and R' 2 and R' 3 are as described herein.